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                         Human-Centric Collaboration and Industry 5.0 Framework in Smart Cities and Communities: Fostering
                         Sustainable Development Goals 3, 4, 9, and 11 in Society 5.0
  https://www.mdpi.com/2624-6511/7/4/68
CONTENTS :

                                                 Intro

From any perspective or how everway you look at it or if you’re confused by ambiguous soft sell and hard sell propaganda, the evolving outlook forecasted for the future, as proposed by globalists through international summits and strategic visions, is deeply rooted toward advancing and unifying humans, nature, and the environment (all living things) with digital and emerging technologies. This vision is ubiquitous across research papers, standardization bodies such as the ITU’s IMT-2030 framework and the IEEE, and corporate roadmaps from leading tech firms, which advocate for seamless connectivity to deliver personalized healthcare, sustainable urban systems, and environmental monitoring. These initiatives, championed by organizations like the World Economic Forum and the United Nations, promise a world with integrated networks and humans. 6G technologies and beyond underscore this commitment, positioning humans and nature as the foundation of a connected, sustainable tomorrow. Indeed, without humans, this conversation would not exist.


Human Centric : What is the 5th Industrial revolution ( 5.0 ) and Society (5.0) ?

Industry 5.0 (the 5th Industrial Revolution) and Society 5.0, reimagine system operations by prioritizing human collaboration through a human-centric ideology. This approach places humans at the core of system operations, integrating digital tools like AI, IoT, and 6G to enhance human capabilities, creativity, and quality of life while addressing societal and environmental challenges outlined in the United Nations Sustainable Development Goals (SDGs). The Human-Centric principle is significant, as it wholeheartedly endorses the integration of humans and digital technologies, emphasizing collaboration and societal progress. In contrast to the provocative biodigital applications like remote telemetry, eHealth, biocyber interfaces, brain-computer interfaces (BCI), and remote neuromodulation, which are narrowly framed as tools for just healthcare services and often raise ethical and societal concerns, Industry 5.0 and Society 5.0 unequivocally advocates for a broader human-centric-digital-fusion societal transformation.
 

Human-Centric Collaboration and Industry 5.0 Framework in Smart Cities and Communities: Fostering Sustainable Development Goals 3, 4, 9, and 11 in Society 5.0
https://www.mdpi.com/2624-6511/7/4/68
The Fifth Industrial Revolution as a Transformative Step towards Society 5.0
https://www.mdpi.com/2075-4698/14/2/19
From Industry 4.0 towards Industry 5.0: A Review and Analysis of Paradigm Shift for the People, Organization and Technology
https://www.mdpi.com/1996-1073/15/14/5221
ERA industrial technologies roadmap on human-centric research and innovation for the manufacturing sector
https://op.europa.eu/en/web/eu-law-and-publications/publication-detail/-/publication/4a5594d1-4ee3-11ef-acbc-01aa75ed71a1
Future of industry 5.0 in society: human-centric solutions, challenges and prospective research areas
https://journalofcloudcomputing.springeropen.com/articles/10.1186/s13677-022-00314-5

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                                               Is COVID-19 pushing us to the Fifth Industrial Revolution (Society 5.0)?
      https://www.researchgate.net/publication/348204227_Is_COVID-19_pushing_us_to_the_Fifth_Industrial_Revolution_Society_50

Industry 5.0 : Industry 5.0 or The 5th Industrial Revolution, represents the next phase of industrial evolution, building upon Industry 4.0 by adding a Human-Centric approach and focusing on sustainability, resilience, and societal value. It emphasizes collaboration between humans and machines, leveraging technology to empower workers and enhance overall efficiency and well-being.
Society 5.0 : Society 5.0 is a concept of a future society proposed by Japan, envisioning a Human-Centered, technology-driven society that balances economic growth with social problem-solving through the merging of cyberspace and physical space. It's also known as the "super-smart society" and aims to create a sustainable and inclusive socio-economic system

Industry 5.0—A Human-Centric Solution
https://www.mdpi.com/2071-1050/11/16/4371

Explainable AI for Industry 5.0: Vision, Architecture, and Potential Directions
https://ieeexplore.ieee.org/document/10526434/figures#figures
From Industry 4.0 towards Industry 5.0: A Review and Analysis of Paradigm Shift for the People, Organization and Technology
https://www.mdpi.com/1996-1073/15/14/5221
Society 5.0 A People-centric Super-smart Society
https://link.springer.com/book/10.1007/978-981-15-2989-4
Society 5.0: Internet as if People Mattered
https://ieeexplore.ieee.org/document/9771320
The Future with Industry 4.0 at the Core of Society 5.0: Open Issues, Future Opportunities and Challenges
https://journalofcloudcomputing.springeropen.com/articles/10.1186/s13677-022-00314-5
                                       1. Development of Human Society   2. The Nature of Society 5.0 click on pics to enlarge
                                                      https://www.keidanren.or.jp/en/policy/2018/095_outline.pdf


                                   

                       What is Cutting Edge Technology?

Cutting-edge technology refers to the latest, most advanced, and innovative technological developments that push the boundaries of what's possible. These technologies are often at the forefront of their fields, offering significant improvements in performance, efficiency, or functionality compared to existing solutions. Examples include advancements in artificial intelligence, quantum computing, biotechnology, and renewable energy systems. Cutting-edge tech is typically characterized by its novelty, high potential for impact, and ongoing refinement, often driving progress in industries and society.

Cutting-Edge Technology in 2025: Revolutionizing the Future
https://epicsoft360.com/cutting-edge-technology-in-2025/
What Is Cutting-Edge Technology? Definition, Examples, and 2025 Trends
https://www.cisin.com/coffee-break/what-is-cutting-edge-technology-definition-examples-and-trends.html
Top 10 Cutting-Edge Technologies to Explode in 2024
https://cmcglobal.com.vn/digtal-transformation/top-10-cutting-edge-technologies-to-explode-in-2024/13
Cutting-Edge Technologies That May Soon Be Making A Big Impact

https://www.forbes.com/councils/forbestechcouncil/2021/02/04/13-cutting-edge-technologies-that-may-soon-be-making-a-big-impact/


                         What is the Bio-Cyber Interface

The Bio Cyber Interface is a core component of the Internet of Bio-Nano Things (IoBNT), enabling seamless communication between biological systems and digital networks. It uses biocompatible nanosensors and signal processing to translate biological signals into digital commands for real-time monitoring and control. Integrated with IoBNT, it supports applications like remote health monitoring, where biological data is transmitted for analysis, enhancing human-machine collaboration and healthcare innovation. In neuroscience, the Bio Cyber Interface, often embodied as brain-computer interfaces (BCIs), connects the human brain to digital systems. It leverages neural signal processing and machine learning to decode brain activity into commands for devices like prosthetics or to deliver sensory feedback. This technology advances neurorehabilitation, restores lost functions, and augments human capabilities by fostering direct brain-machine interaction. 

A Systematic Review of Bio-Cyber Interface Technologies and Security Issues for Internet of Bio-Nano Things
https://ieeexplore.ieee.org/document/9467302 
Biologically Inspired Bio-Cyber Interface Architecture and Model for Internet of Bio-NanoThings Applications
https://ieeexplore.ieee.org/document/7497004
Brain-computer interface restores natural speech after paralysis
https://www.nih.gov/news-events/nih-research-matters/brain-computer-interface-restores-natural-speech-after-paralysis
Bio-Inspired Information PathwaysFrom Neuroscience to Neurotronics
https://link.springer.com/book/10.1007/978-3-031-36705-2   
Bioinspired molecular communications system for targeted drug delivery with IoBNT-based sustainable biocyber interface
https://www.sciencedirect.com/science/article/abs/pii/S0045790624003793
A Biologically Inspired and Protein-Based Bio-Cyber Interface for the Internet of Bio-Nano Things
https://www.sciencedirect.com/science/article/pii/S2590137024001365
CRISPR-Enabled Graphene-Based Bio-Cyber Interface Model for In Vivo Monitoring of Non-Invasive Therapeutic Processes
https://ieeexplore.ieee.org/document/10376156



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A Typical Internet of Bio-Nano Things Architecture, where a bio-chemical signal from inside the human body is converted into electromagnetic signal via Bio Cyber Interface, and transmitted through Bluetooth or equivalent technology towards medical server for further analysis and processing.
https://ieeexplore.ieee.org/document/9467302

IEEE White Paper 2020 : PANACEA: An Internet of Bio-NanoThings Application for Early Detection and Mitigation of Infectious Diseases Ian F. Akyildiz; Maysam Ghovanloo; Ulkuhan Guler; Tevhide Ozkaya-Ahmadov; A. Fatih Sarioglu; Bige D. Unluturk.  https://ieeexplore.ieee.org/document/9149878

The PANACEA Project (a solution or remedy for all difficulties or diseases in Latin) presents a Cyber-Physical System leveraging the Internet of Bio-NanoThings (IoBNT) for early detection and mitigation of infections in immunocompromised patients. A Bio-Cyber Interface enables communication between bio-nanosensors and external digital networks for real-time health monitoring that aligns with the Wireless Body Area Networks (WBANs).
System Architecture and Components below:

Intra-Body Network and BNT Sensors: Bio-nanosensors (BNTs), implanted or worn, detect quorum-sensing (QS) molecules indicating bacterial infections using electrochemical or bacterial sensors. Molecular communication (MC) models QS diffusion in tissues, with simulations showing faster detection than traditional culturing.
Body-to-Hub Communication and Wearable Hub: BNTs transmit data to a wearable hub (patch or smartwatch) using magnetic induction (MI) for low-power data and power transfer, ensuring safe electromagnetic exposure. The hub aggregates data, provides visualization, and sends infection alerts to patients and providers.
External Network and Communication Systems: The hub forwards data to cloud or clinic databases via Bluetooth Low Energy (BLE) or Near-Field Communication (NFC). MC models infections as a MIMO molecular channel, MI supports body-to-hub communication, and BLE/NFC ensures external connectivity.

Functions and Applications:
Early Detection and Drug Delivery:
Supports early infection detection, active drug delivery (BNTs/hubs releasing antibiotics, modeled via MC for biodistribution), passive delivery (provider- or patient-triggered drugs/alerts), and quorum quenching to disrupt QS, reducing mortality and costs in immunocompromised patients.

Personalized Medicine: Sensor calibration enables data visualization and personalized treatment, tailoring interventions to individual patient profiles.
Disease Tracking and Epidemic Monitoring: Enables real-time tracking of diseases like COVID-19 using BNTs to detect pathogen biomarkers (e.g., SARS-CoV-2 antigens). Wearable hubs and BLE/NFC transmit data to cloud databases for analytics, identifying infection patterns and supporting ongoing monitoring and contact tracing for public health responses.

Cybersecurity Challenges
The system prioritizes health data protection through lightweight authentication, homomorphic encryption, and Intel SGX to mitigate hardware and side-channel attacks. Key challenges include:

Bio-Cyber Interface: Vulnerable to manipulation or side-channel attacks, risking false infection alerts or data integrity loss.
Resource-Constrained BNTs: Limited power and computation restrict robust cryptography, risking unauthorized access.
Data Privacy/Integrity: Breaches in cloud/clinic databases could compromise privacy or treatment accuracy.
MC Standardization: Lack of a unified MC framework (per IEEE 1906.1-2015) risks inconsistent protections, potentially disrupting QS-based communication. These issues could undermine real-time detection, drug delivery, and privacy, critical for immunocompromised patients.

                                                                                     Figure 1 from the white paper
The Diagram illustrates the Internet of Bio-NanoThings (IoBNT) framework, detailing the Bio-cyber interface’s role in connecting Bio-Nanosensor networks to external systems. It outlines the following steps of data transmission for health monitoring:
1. Intra-Body Sensing: Bio-nanosensors, termed BNTs/biosensors, detect infection-related quorum-sensing (QS) molecules within the body. 2. Molecular Communication: These sensors communicate internally using molecular signals, transmitting data through body tissues. 3. Wearable Hub Relay: A wearable hub (worn externally as a patch or smartwatch) receives data from BNTs via magnetic induction (MI), aggregating and visualizing infection alerts. 
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4. Bio-cyber Interface Conversion: The Bio-cyber interface converts molecular signals into digital data for external processing. 
5. Transmission via Cell Phone: The digital data is relayed to a cell phone, facilitating connectivity to the internet.
6. External System Integration: The cell phone forwards data through the internet to cloud/clinic databases, enabling secure storage, processing, and remote monitoring by healthcare providers, with support for active/passive drug delivery and quorum quenching. https://ieeexplore.ieee.org/document/9149878
A Detailed Video presentation by Ian F. Akyildiz complementing "The PANACEA: An Internet of Bio-NanoThings Application for Early Detection and Mitigation of Infectious Diseases" IEEE White paper.

Science and Society Meetings -XI, Prof. Dr.Ilhan Fuat Akyildiz, Georgia University
https://www.youtube.com/watch?v=BhYpi9cRenY


ITU.PANACEA: A Cyber-Physical System for Early
Detection and Mitigation of Infections

https://www.itu.int/en/ITU-T/academia/kaleidoscope/2019/Documents/Presentations/Keynote%20speech_Ian_Akyildiz.pdf

work in progress


Cutting Edge Tech revealed in ISO/IEC JTC 1 white paper.

ISO/IEC JTC 1, is an alliance between the International Organization for Standardization (ISO) and the International Electrotechnical Commission (IEC), was founded to establish Global Information Technology standards. Overseen by the American National Standards Institute (ANSI), it unites national standards bodies from numerous countries to advance ICT innovations that focus on areas like AI, cybersecurity, and multimedia, ensuring interoperable, cutting edge tech solutions while harmonizing ISO and IEC efforts. Its relationship with the United Nations’ 2030 Agenda and its sustainable development framework is deeply synergistic, as JTC 1’s work fosters technological foundations that support global priorities, driving progress across multiple dimensions of sustainability i.e economic, social, and environmental, through innovation, efficiency, and equitable access to advanced systems. Dr. François Coallier, a key figure in JTC 1, reveals transformative technologies in his white papers that merge biology and tech in revolutionary ways. Here’s a list of some cutting-edge advancements:
Human Augmentation: Enhancing human potential with tech, from brain-computer interfaces to strength boosting exoskeletons.
Geoengineering: Leveraging Information Technology (IT) to monitor or manipulate environmental systems, aiding climate change solutions.
Biohacking: Experimenting with biological tweaks, such as implants or gene edits for health and performance.
Robotics and Cyborgs: Merging robotics with biology, including biointegrated machines or IoT powered industrial robots.
Synthetic Biology: Engineering artificial biological systems for medicine, energy, or ecological restoration.
Quantum Computing Interfaces: Connecting quantum tech with biological data for rapid processing in healthcare or research.
Neurotechnology: Developing neural implants or mind-machine interfaces for communication, therapy, or cognitive enhancement.
Smart Dust: Deploying tiny, networked sensors to discreetly monitor ecosystems or human health.
Digital Twins of Biological Systems: Creating virtual models of organisms or ecosystems for real-time insights and forecasting.
Genomics: Analyzing genomes with IT to unlock personalized medicine and evolutionary discoveries.
Genetic Engineering: Precisely editing DNA using digital tools, advancing agriculture, therapy, and bio-design.
CRISPR-Cas9: A game changing gene editing method guided by IT, enabling exact DNA modifications for medical or ecological gains.
Neurobotics: Blending neuroscience and robotics, like brain-controlled prosthetics or neural repair robots.
Cyborg Technologies: Advancing hybrid human machine systems, such as bio electronic enhancements for sensory or physical upgrades.
Nanotechnologies: Harnessing nanoscale materials and devices, like nanobots for drug delivery or tissue repair, integrated with digital control systems.


ISO/IEC JTC 1
https://en.wikipedia.org/wiki/ISO/IEC_JTC_1
ISO/IEC JTC 1 Official Page
https://jtc1info.org/
ISO contributes to the Sustainable Development Goals SDG

https://www.iso.org/sdg
ISO Information and Communications Technology ICT PDF
https://www.iso.org/files/live/sites/isoorg/files/developing_standards/docs/en/jtc1_mission_brochure_2014_final.pdf
How standards help achieve SDGs
https://jtc1info.org/how-standards-for-ict-help-achieve-the-un-sdgs/



An Abundance of Cutting Edge Technologies revealed in pages 7, 8, and 9 ( below ) from Dr. François Coalliers ISO/IEC JTC White Paper, integrating with the UN 2030 Agenda-Sustainable Development Goals and Bio Digital Convergence at the Helm. "Internet of Things and Digital Twin applications in the Health Sector"  https://www.iec.ch/system/files/2023-10/wsdcombinedpdf_0.pdf
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